SEASON ONE
The season begins with Meredith enrolling as an intern at Seattle Grace Hospital, and focuses chiefly on the first few weeks of the interns' internship, including their training under Miranda Bailey, Meredith and Derek's new-found relationship and Meredith's mother's Alzheimer's disease. Subplots include Burke's rivalry with Derek and sexual relationship with Cristina, Izzie's attempts to be recognized as a doctor and conceal her past, George's crush on Meredith and his relationship with Olivia and the revelations of Richard's past. The season ends with the arrival of Derek's estranged wife, Addison.SEASON TWO
The second season focuses on Meredith and Derek's relationship, which comes to an abrupt halt when it is revealed that Derek is married to neo-natal surgeon Addison Montgomery. Izzie and Alex embark on a relationship of their own, which is cut short when Izzie falls for heart patient Denny Duquette. Bailey becomes pregnant, and more is revealed about her personal life.
The season focused on Izzie's struggle to let go of Denny, Meredith's choice between Derek and her new boyfriend Finn, the ramifications of Burke's gunshot injury and the decision between the four attending surgeons as to the new Chief of Surgery and between the residents for Chief Resident. As the season came to a close, Burke called off his wedding to Cristina, Chief Webber stayed on as the Chief of Surgery, Callie was appointed Chief Resident, and George learned he had failed the final intern exam. The relationship between Derek and Meredith, as well as the triangle between Callie, George, and Izzie were left unresolved. Addison decides to start a new life in Los Angeles, transferring to the spin-off Private Practice.
Erica Hahn replaced Burke as head of cardiothoracic surgery. Chyler Leigh guest starred in the final two episodes of season three as Lexie Grey, a new intern and Meredith's younger half-sister. Fourth season guest stars included Seth Green of Buffy the Vampire Slayer fame, who appeared in a two-part episode. Lauren Stamile plays a scrub nurse named Rose, who became a potential love interest for Derek.Dawson's Creek alumnus Joshua Jackson was scheduled to make his return to television in a multi-episode arc as a doctor with his first appearance in the season's eleventh episode
The season focused on Mark Sloan pursuing a committed relationship with Lexie Grey despite Derek and Meredith's word not to, the discovery of Meredith's mother's journals from when she was a resident, Meredith's reaction to the journals, Lexie and her fellow interns performing procedures on each other, the appearance of Meredith's old friend Sadie, the reappearance of Denny Duquette, who appears to Izzie Stevens as a hallucination, only to later learn that she was terminally ill (further speculating rumors that Heigl was looking for a departure from the show) the intensity rising between the residents as an opportunity for a solo surgery comes into play, and various other staff romances.SEASON SIX
The sixth season introduced several new residents joining the Seattle Grace Hospital staff because of the merger with Mercy West Hospital. Those residents include Nora Zehetner's Dr. Reed Adamson, Jesse Williams' Dr. Jackson Avery, whose grandfather is the famous Harper Avery, Robert Baker's Dr. Charles Percy, who is hated on by almost everyone and Sarah Drew's Dr. April Kepner, who was fired in episode six and rehired in episode thirteen. Kim Raver joined the cast on November 12, 2009 as Dr. Teddy Altman, a cardiothoracic surgeon and Iraqi-war veteran who served with Dr. Owen Hunt.The Grey's Anatomy DVD collection is a great Christmas present to the show's loyal fans. Grab one now! Merry Christmas and a Happy New Year!
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